Methanesulfonyl chloride → 2-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

HRID 2089235Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2089235
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[N:12]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22].[CH3:25][S:26](Cl)(=[O:28])=[O:27]>C(Cl)Cl>[CH3:25][S:26]([N:8]1[C:9]2[C:5](=[CH:4][C:3]([C:2]([F:23])([F:1])[F:24])=[CH:11][CH:10]=2)[C:6]([N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[N:7]1)(=[O:28])=[O:27]

Komponenten

4

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 585488622-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

Produkt 1

HCID 585487162-(1-Methanesulfonyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dioneAusbeute 70,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione (350 mg, 1.06 mmol), TEA (0.3 mL, 2.12 mmol) in DCM (5 mL) was treated with MsCl (182 mg, 1.59 mmol) at 0° C. for 2 hours. The solvent was removed and the residue was purified by silica gel column chromatography using hexanes:ethyl acetate 1:1 to give the title compound as white solid (305 mg, 69%).

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-b7517ea130944880a97ff1731deac2ef
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436023B2

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