Dimethylformamide → (4-Bromo-3-methoxy-2naphtyl)-triphenylsilane

HRID 2090132

Reaktionsgleichung

Reaktionsgleichung von HRID 2090132
[CH3:1][O:2][C:3]1[C:4]([Si:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][C:6]2[C:11]([CH:12]=1)=[CH:10][CH:9]=[CH:8][CH:7]=2.[Br:32]N1C(=O)CCC1=O.CN(C)C=O.CCOC(C)=O>O>[Br:32][C:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([Si:13]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:3]=1[O:2][CH3:1]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 67184N-bromobutanimideHCID 42290602-Methoxy-3-(triphenylsilyl)naphthalene

Produkt 1

HCID 86653240(4-Bromo-3-methoxy-2naphtyl)-triphenylsilaneAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 150 mL Schlenk flask was charged with 4.68 g of (3-methoxy-2-naphthyl)(triphenyl)silane (11.23 mmol) and 2.20 g of N-Bromosuccinimide (NBS) (12.36 mmol) under argon followed by addition of 10 mL of dimethylformamide (DMF). The resultant mixture was stirred overnight at room temperature, then diluted with 500 mL of water and extracted with 3 times 50 mL of CH2Cl2. The combined organic extracts were washed with 200 mL of water, brine and dried over Na2SO4. The product was purified by passing through short column (silica) using a mixture heptane:EtOAc in a ratio of 15:1 as eluent to afford 5.28 g of product as off-white solid (10.66 mmol) with a yield of 96%.

Aufarbeitung

  1. extractionextracted with 3 times 50 mL of CH2Cl2
  2. washThe combined organic extracts were washed with 200 mL of water, brine
  3. dry with materialdried over Na2SO4
  4. customThe product was purified

Quellen und Nachweise

ORD-Eintrag
ord-cbd7c1116b21420aa37a89678e0f5b8b
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436133B2

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