Benzyl 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1-methyl-1H-pyrrole-2-carboxylate → HCID 59402268, Verbindung

HRID 2090401Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2090401
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[CH:20]=[C:21]([C:25]([O:27]CC5C=CC=CC=5)=[O:26])[N:22]([CH3:24])[CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)[N:3]=1>CO.[Pd]>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[CH:20]=[C:21]([C:25]([OH:27])=[O:26])[N:22]([CH3:24])[CH:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:35]2[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]2)[N:3]=1

Komponenten

4

Edukt 1

HCID 59402315Benzyl 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1-methyl-1H-pyrrole-2-carboxylate

Produkt 1

HCID 59402268HCID 59402268, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Pd/C (25.0 mg, 10 wt. % loading dry basis, matrix activated carbon, wet support, Degussa type E101 NE/W) was added to a solution of benzyl 4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1-methyl-1H-pyrrole-2-carboxylate (0.10 g, 0.18 mmol) in methanol (2.0 mL) and then the reaction was stirred under hydrogen (balloon) for 2 h. LCMS showed the reaction was complete. The reaction mixture was filtered. The solvent was removed under reduced pressure to give the product which was directly used in the next step reaction without further purification. LCMS (M+H)+: m/z=462.3.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. customThe solvent was removed under reduced pressure
  3. customto give the product which
  4. customwas directly used in the next step reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-7b9e1059193244aca1754eb2fb876cb3
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436008B2

Notizen zur Reaktion

Wird geladen…