Water → 4-(4-Bromophenyl)-6,7-dimethoxy-2-naphthol

HRID 2090515Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2090515
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=[O:22])[CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([O:20][CH3:21])[CH:13]=2)=[CH:4][CH:3]=1.O>P(=O)(O)(O)O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[CH:13][C:14]([O:20][CH3:21])=[C:15]([O:18][CH3:19])[CH:16]=3)[CH:11]=[C:10]([OH:22])[CH:9]=2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 591887201-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione

Produkt 1

HCID 591887014-(4-Bromophenyl)-6,7-dimethoxy-2-naphtholAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1004Phosphoric AcidLösungsmittel

Versuchsvorschrift

1-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)butane-1,3-dione (3 g, 8 mmol) in 85% phosphoric acid was heated at 70° C. for 20 h. The resulting solution was cooled, poured into water (150 ml) and filtered. The residue was dissolved in dichloromethane (50 ml), washed with water (50 ml), dried (MgSO4) and the solvent was removed under reduced pressure to give the title compound (2.56 g, 90%) as a brown powder.

Aufarbeitung

  1. temperatureThe resulting solution was cooled
  2. filtrationfiltered
  3. dissolutionThe residue was dissolved in dichloromethane (50 ml)
  4. washwashed with water (50 ml)
  5. dry with materialdried (MgSO4)
  6. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4a210246bf5546758795975eb2fcff96
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436184B2

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