Hydrochloric Acid → 7-Tert-butyl-chroman-4-ol

HRID 2092144

Reaktionsgleichung

Reaktionsgleichung von HRID 2092144
[C:1]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][CH2:10][CH:11]1[O:16]CCCO1)([CH3:4])([CH3:3])[CH3:2].Cl>O1CCCC1.C(OCC)C>[C:1]([C:5]1[CH:6]=[C:7]2[C:17]([CH:11]([OH:16])[CH2:10][CH2:9][O:8]2)=[CH:18][CH:19]=1)([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 595485522-[2-(3-Tert-butyl-phenoxy)-ethyl]-[1,3]dioxane

Produkt 1

HCID 595485267-Tert-butyl-chroman-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The intermediate from step A was dissolved in 20 ml tetrahydrofuran. Concentrated hydrochloric acid (20 mL) was added, and the reaction mixture was stirred at ambient temperature for 4 hours, diluted with diethyl ether and washed with water. The isolated organic layer was dried with magnesium sulfate, filtered and the solvent removed under reduced pressure to give 2.87 g of crude 7-tert-butyl-chroman-4-ol which was used without further purification.

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe isolated organic layer was dried with magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6c7e8dd576bd4647ba727bb644ad6e07
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440691B2

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