Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene → 4-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

HRID 2092687

Reaktionsgleichung

Reaktionsgleichung von HRID 2092687
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH:11]([CH3:16])[C:12]([F:15])([F:14])[F:13])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[F:13][C:12]([F:14])([F:15])[CH:11]([CH3:16])[O:10][C:7]1[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=1

Komponenten

4

Edukt 1

HCID 66577895Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene

Produkt 1

HCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-anilineAusbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

Nitro-4-(2,2,2-trifluoro-1-methyl-ethoxy)-benzene (6.74 g) was dissolved in MeOH (70 mL). Pd on carbon (10% Pd, 500 mg) was added and the mixture was hydrogenated at RT for 12 hours. The suspension was filtered and the filtrate was concentrated in vacuo to provide the title compound as a brown liquid (5.8 g). Rf: 0.38 (silica gel, ether/heptane 1:1). MS (m/e): 206.1 (MH+).

Aufarbeitung

  1. filtrationThe suspension was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2d8ee7dcd7514d0fa0a82721d3c39024
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440710B2

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