Water → HCID 59406814, Verbindung

HRID 2093350

Reaktionsgleichung

Reaktionsgleichung von HRID 2093350
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13](=[O:16])[NH:14][N:15]=2)[CH:5]=[C:6]([F:9])[C:7]=1[F:8].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:24][C:25]1[CH:33]=[CH:32][C:28]2=[N:29][S:30][N:31]=[C:27]2[CH:26]=1.O>CN(C=O)C>[N:29]1[S:30][N:31]=[C:27]2[CH:26]=[C:25]([CH2:24][N:14]3[C:13](=[O:16])[CH:12]=[CH:11][C:10]([C:4]4[CH:5]=[C:6]([F:9])[C:7]([F:8])=[C:2]([F:1])[CH:3]=4)=[N:15]3)[CH:33]=[CH:32][C:28]=12

Komponenten

6

Edukt 4

HCID 962WaterHCID 10796Cesium carbonateHCID 5910045-(Bromomethyl)-2,1,3-benzothiadiazoleHCID 594068096-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one

Produkt 1

HCID 59406814HCID 59406814, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

3.0 g (13.3 mmol) of 6-(3,4,5-trifluorophenyl)-2H-pyridazin-3-one and 4.8 g (14.4 mmol) of caesium carbonate are suspended in 250 ml of DMF, 3.0 g (13.3 mmol) of 5-(bromomethyl)2,1,3-benzothiadiazole are added, and the mixture is stirred at room temperature. After 15 h, 110 ml of water are added to the reaction mixture, which is then stirred at room temperature for 2 h. The resultant precipitate is filtered off with suction and washed with water and dried in vacuo.

Aufarbeitung

  1. stirringis then stirred at room temperature for 2 h
  2. filtrationThe resultant precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-25b3a76f5f8b4313868866a40cd205f5
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08445489B2

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