Lithium Hydroxide → 4-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid

HRID 2094258

Reaktionsgleichung

Reaktionsgleichung von HRID 2094258
[N:1]1([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][C:9]=2[N+:18]([O-:20])=[O:19])[CH2:6][CH2:5][O:4][CH2:3][C:2]1=[O:7].[OH-:21].[Li+]>CO>[C:2]([CH2:3][O:4][CH2:5][CH2:6][NH:1][C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[N+:18]([O-:20])=[O:19])([OH:21])=[O:7]

Komponenten

4

Edukt 2

HCID 3939Lithium HydroxideHCID 67049467Methyl 4-(morpholin-3-on-4-yl)-3-nitro-benzoate

Produkt 1

HCID 667319084-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

400 mg (1.43 mmol) methyl 4-(morpholin-3-on-4-yl)-3-nitro-benzoate are dissolved in 15 ml of methanol and combined with 4.5 ml (4.5 mmol) 1-molar lithium hydroxide solution. The mixture is stirred for 2 hours at ambient temperature. Then it is evaporated down i. vac., the residue is diluted with water, cooled in the ice bath and acidified with 2-molar hydrochloric acid. After 10 minutes cooling in the ice bath the precipitate formed is filtered off, washed with water until neutral and dried at 50° C. in the drying cupboard.

Aufarbeitung

  1. customThen it is evaporated down i
  2. addition, the residue is diluted with water
  3. temperaturecooled in the ice bath
  4. temperatureAfter 10 minutes cooling in the ice bath the precipitate
  5. customformed
  6. filtrationis filtered off
  7. washwashed with water until neutral and
  8. customdried at 50° C. in the drying cupboard

Quellen und Nachweise

ORD-Eintrag
ord-b3f893f4770e4d33a224e41d4f38c83d
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08445525B2

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