Dimethylformamide → 4-Chloro-4'-methylsulfonylmethylbenzophenone

HRID 2096

Reaktionsgleichung

Reaktionsgleichung von HRID 2096
Br[CH2:2][C:3]1[CH:17]=[CH:16][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:4]=1.[CH3:18][S:19]([O-:21])=[O:20].[Na+].CN(C)C=O>O>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]([C:6]2[CH:16]=[CH:17][C:3]([CH2:2][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:4][CH:5]=2)=[O:8])=[CH:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 2733271Sodium methanesulfinateHCID 98396514-(4-Chlorobenzoyl)benzyl bromide

Produkt 1

HCID 187799134-Chloro-4'-methylsulfonylmethylbenzophenoneAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4-bromomethyl-4'-chlorobenzophenone (3.1 g) and sodium methanesulfinate (1.5 g) were added to N,N-dimethylformamide (50 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.8 g, melting point: 164° to 166° C., yield: 90%).

Aufarbeitung

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe ethyl acetate layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationEthyl acetate was distilled off under reduced pressure
  5. washThe residual solid was washed with n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-ade4f0eddda041248b4ac3c87079d5f2
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05728699

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