Hydrochloric Acid → HCID 178444144, Verbindung

HRID 2096111

Reaktionsgleichung

Reaktionsgleichung von HRID 2096111
[CH2:1]([O:3][C:4](=[O:34])[C@@:5]([OH:33])([CH3:32])[CH2:6][N:7]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[F:31])=[CH:20][CH:19]=1)[NH:8][C:9]([C:11]1[O:15][N:14]=[C:13]([OH:16])[CH:12]=1)=[O:10])[CH3:2].[CH2:35](O)[CH2:36][CH2:37][CH2:38][CH2:39]CC.Cl.O1CCOCC1>>[CH2:1]([O:3][C:4](=[O:34])[C@@:5]([OH:33])([CH3:32])[CH2:6][N:7]([CH2:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]=2[F:31])=[CH:22][CH:23]=1)[NH:8][C:9]([C:11]1[O:15][N:14]=[C:13]([OH:16])[CH:12]=1)=[O:10])[CH2:2][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 8129HeptanolHCID 312751,4-DioxaneHCID 178472219HCID 178472219, Verbindung

Produkt 1

HCID 178444144HCID 178444144, VerbindungAusbeute 95 %

Versuchsvorschrift

(R)-3-[N-(5′-Chloro-2′-fluorobiphenyl-4-ylmethyl)-N′-(3-hydroxy-isoxazole-5-carbonyl)-hydrazino]-2-hydroxy-2-methyl-propionic acid ethyl ester (100 mg, 0.2 mmol) was dissolved in 1-heptanol (6 g, 50 mmol), followed by the addition of 4 M HCl in dioxane (1 mL, 4 mmol). The resulting mixture was stirred at room temperature for 8 hours, then evaporated under reduced pressure and purified (Interchim reverse phase chromatography column). The pure fractions were lyophilized to yield the title compound (27 mg, 95% purity). MS m/z [M+H]+ calc'd for C28H33ClFN3O6, 562.20; found 562.2.

Aufarbeitung

  1. customevaporated under reduced pressure
  2. custompurified (Interchim reverse phase chromatography column)

Quellen und Nachweise

ORD-Eintrag
ord-128a7c801c89416eb75e3a939e413d76
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08449890B2

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