Oxalyl chloride → 3-Methyl-2-oxo-1,3-benzoxazole-5-carbonyl chloride

HRID 2096860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2096860
[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([C:11](O)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:14].C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][N:2]1[C:6]2[CH:7]=[C:8]([C:11]([Cl:18])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:14]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 99901743-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-5-carboxylic acid

Produkt 1

HCID 104431423-Methyl-2-oxo-1,3-benzoxazole-5-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of 3-methyl-2-oxo-2,3-dihydro-benzooxazole-5-carboxylic acid (2.50 g, obtained in Example 116, step 5) in CH2Cl2 (40 mL) were added nine drops of DMF and oxalylchloride (1.78 mL). The mixture was stirred at room temperature for 2 hours and was then concentrated to dryness. The resulting solid was dried at high vacuum over night. The title compound was abtained as a colorless solid (2.85 g, 99%). MS (EI)=211.0 [M+].

Aufarbeitung

  1. concentrationwas then concentrated to dryness
  2. customThe resulting solid was dried at high vacuum over night

Quellen und Nachweise

ORD-Eintrag
ord-ae16a04c160e4a83a0a41ee08d543e4d
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450313B2

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