Water → 1-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

HRID 2097270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2097270
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:26]N1C(=O)CCC1=O.O>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:12]([Br:26])=[CH:11][C:10]=1[C:23](=[O:25])[CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 3194691-(2,4-Bis(benzyloxy)phenyl)ethanone

Produkt 1

HCID 247744411-(2,4-Bis-benzyloxy-5-bromo-phenyl)-ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Versuchsvorschrift

51.2 g of 1-(2,4-Bis-benzyloxy-phenyl)-ethanone (0.154 mol, 1 eq) were dissolved in 250 ml DMF. 27.42 g N-bromosuccinimide (0.154 mol, 1 eq) in 100 ml DMF were added dropwise. The mixture was stirred at room temperature over night. The reaction mixture was poured onto 700 ml of water and the precipitate filtered off. The filter cake was rinsed with water and the colourless solid was recrystallised from 370 ml acetonitrile.

Aufarbeitung

  1. filtrationthe precipitate filtered off
  2. washThe filter cake was rinsed with water
  3. customthe colourless solid was recrystallised from 370 ml acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-33b1552949b14b74b3519fc997b151de
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450310B2

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