Sodium borohydride → HCID 58941864, Verbindung

HRID 2097636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2097636
[CH:1]([C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9])=[O:2].[BH4-].[Na+]>C(O)C>[OH:2][CH2:1][C:3]1[S:7][N:6]=[N:5][C:4]=1[C:8]([O:10][CH3:11])=[O:9]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 14913987Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate

Produkt 1

HCID 58941864HCID 58941864, VerbindungAusbeute 75,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Methyl 5-formyl-1,2,3-thiadiazole-4-carboxylate (460.0 mg, 0.0026 mol) was dissolved in ethanol (40 mL) and sodium tetrahydroborate (50 mg, 0.0013 mol) was added at 0° C. The orange solution was allowed to warm to room temp and was stirred for 30 minutes. The reaction was quenched with acetic acid and then purified by preparative LCMS to give the desired product (340 mg, 73%). MF═C5H6N2O3S; LCMS calculated for C5H7N2O3S(M+H)+: m/z=175.1.

Aufarbeitung

  1. customThe reaction was quenched with acetic acid
  2. custompurified by preparative LCMS

Quellen und Nachweise

ORD-Eintrag
ord-32acbc96fdb5443c97feed86e78f51d5
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450351B2

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