Methanol → 2-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

HRID 2098835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2098835
CS[CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].O[O:18][S:19]([O-:21])=O.[K+].[CH3:23]O>O>[CH3:23][S:19]([CH2:3][CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16])(=[O:21])=[O:18]

Komponenten

5

Edukt 3

HCID 887MethanolHCID 134589972-[3-(Methylsulfanyl)propyl]-1H-isoindole-1,3(2H)-dioneHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 134590592-(3-(Methylsulfonyl)propyl)isoindoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of 2-(3-methylsulfanyl-propyl)-isoindole-1,3-dione (440 mg) in methanol (10 mL) was added a solution of oxone (1.73 g) in water (10 mL) and the reaction stirred at room temperature for 16 h. The reaction was then diluted with water (20 mL) and extracted into dichloromethane (2×20 mL). The combined organics were washed with aqueous brine solution (2×20 mL), dried (MgSO4) and reduced in vacuo to give 2-(3-methanesulfonyl-propyl)-isoindole-1,3-dione as a white solid.

Aufarbeitung

  1. extractionextracted into dichloromethane (2×20 mL)
  2. washThe combined organics were washed with aqueous brine solution (2×20 mL)
  3. dry with materialdried (MgSO4)

Quellen und Nachweise

ORD-Eintrag
ord-fcc3c765e5f24ac3bc235062975207a9
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450315B2

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