Trifluoroacetic acid → 2-[(3-chloro-4-hydroxybenzoyl)(methyl)amino]-N-isopropyl-5-phenoxybenzamide

Beteiligte Stoffe

Reaktionsschritte

A solution of 44C (30 mg, 0.05 mmol) in CH2Cl2 (1 mL) at 0° C. was treated with TFA (0.05 mL). The solution was warmed to room temperature and stirred for 16 hours. The crude mixture was purified by chromatography (SiO2, 50% EtOAc in hexane) to afford 44D (15 mg, 68%). HPLC Retention Time=3.09 min (YMC ODSA 5 u C18 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm) [M+H+]=439.

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