Malonic Acid → HCID 68858098, Verbindung

HRID 2100736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2100736
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:9]=O.C(O)(=O)[CH2:20][C:21]([OH:23])=[O:22].N1CCCCC1>N1C=CC=CC=1>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH:9]=[CH:20][C:21]([OH:23])=[O:22])[CH:11]=[CH:12][C:13]=1[O:14][CH2:15][CH2:16][O:17][CH3:18]

Komponenten

5

Edukt 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 160633913,4-Bis(2-methoxyethoxy)benzaldehyde

Produkt 1

HCID 68858098HCID 68858098, VerbindungAusbeute 93,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a solution of 3,4-Bis-(2-methoxy-ethoxy)-benzaldehyde (19 g, 72.4 mmol) in pyridine (60 ml), malonic acid (11.3 g, 108.6 mmol) was added, followed by piperidine (2 ml), the resulting mixture was heated at 110° C. for 6 hs under N2. After removal of most of pyridine, the residue was poured into water (200 ml) and acidified to PH=3 by aq.HCl. The precipitate was collected and dried to give product (20 g, 93.3%). LC-MS: m/e 295 (M−1)

Aufarbeitung

  1. customAfter removal of most of pyridine
  2. additionthe residue was poured into water (200 ml)
  3. customThe precipitate was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-3ce3f9688c5047e18d349aa55d38943f
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07572809B2

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