Water → Phenol, 2,3-dimethyl-4-(phenylmethoxy)-

HRID 2102989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2102989
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([O-:12])([O-])=O.[K+].[K+].[OH2:15]>CN(C=O)C>[CH2:1]([O:15][C:3]1[CH:4]=[CH:5][C:9]([OH:12])=[C:7]([CH3:6])[C:2]=1[CH3:1])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium Carbonate

Produkt 1

HCID 23290216Phenol, 2,3-dimethyl-4-(phenylmethoxy)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 2,3-dimethyl-1,4-dihydroquinone (5 g) and benzyl bromide (6.2 g) and K2CO3 (10 g) in DMF (50 mL) was stirred at 120° C. for 5 h. The mixture was poured into water and extracted with EtOAc. The EtOAc was washed with water, dried and evaporated. The residue was purified by silica gel column eluting with 10% EtOAc in hexane to give 3.2 g of 4-benzyloxy-2,3-dimethyl-phenol as a pale solid.

Aufarbeitung

  1. extractionextracted with EtOAc
  2. washThe EtOAc was washed with water
  3. customdried
  4. customevaporated
  5. customThe residue was purified by silica gel column
  6. washeluting with 10% EtOAc in hexane

Quellen und Nachweise

ORD-Eintrag
ord-843271ad65f94a439d31ea758f985c97
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07576094B2

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