Hydroxyamine hydrochloride → 1h-Imidazo[4,5-c][1,5]naphthyridine

HRID 2105454Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2105454
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][N:10]=2)[N:5]=[CH:4][C:3]=1[NH-:12].ClC1C2C(=CC=CC=2)[N:17]=[CH:16]C=1[NH-].Cl.NO>>[NH:17]1[C:2]2[C:11]3[N:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:5]=[CH:4][C:3]=2[N:12]=[CH:16]1

Komponenten

4

Edukt 3

HCID 443297Hydroxyamine hydrochlorideHCID 86625942HCID 86625942, VerbindungHCID 86625943HCID 86625943, Verbindung

Produkt 1

HCID 1784207351h-Imidazo[4,5-c][1,5]naphthyridine

Versuchsvorschrift

In step (7) of Reaction Scheme II, an N-(4-chloro[1,5]naphthyridin-3-yl)amide or N-(4-chloroquinolin-3-yl)amide of Formula XXXII is reacted with a hydroxylamine hydrochloride of Formula R1ONH2.HCl and cyclized to provide a 1H-imidazo[4,5-c][1,5]naphthyridine or a 1H-imidazo[4,5-c]quinoline of Formula XXXIII. The reaction can be carried out using the method described in step (3) of Reaction Scheme I.

Aufarbeitung

  1. customIn step (7) of Reaction Scheme II

Quellen und Nachweise

ORD-Eintrag
ord-3d95590124734aa587f6d5bd3fa2a929
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07579359B2

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