O[CH:2]1[CH:9]2[CH2:10][C:5]3([C:11]4[NH:19][C:18]5[C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH3:23])[C:15](=[O:24])[N:14]([CH2:25][CH2:26][CH3:27])[C:13]=5[N:12]=4)[CH2:6][CH:7](O2)[CH:3]1O3.[C:28]([OH:34])(=[O:33])[CH2:29][C:30](O)=O.N1C=CC=C[CH:36]=1>N1CCCCC1>[O:24]=[C:15]1[N:14]([CH2:25][CH2:26][CH3:27])[C:13]2[N:12]=[C:11]([C:5]34[CH2:7][CH2:3][C:2]([CH:30]=[CH:29][C:28]([OH:34])=[O:33])([CH2:36][CH2:6]3)[CH2:9][CH2:10]4)[NH:19][C:18]=2[C:17](=[O:20])[N:16]1[CH2:21][CH2:22][CH3:23]4-(2,6-Dioxo-1,35-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane 1-carbaldehyde (XI, Example 9, 0.490 g, 1.32 mmol) is added to a mixture of malonic acid (0.275 g, 2.64 mmol), pyridine (2 ml), and piperidine (1 drop). The mixture is heated to 1000 for 16 hours. Four additional equivalents of malonic acid are added and heating continued for another 16 hours until consumption of aldehyde ceases, to give the title compound.
Wird geladen…