Sodium Hydroxide → 1,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one

HRID 2106055Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2106055
C(OP([C:9]([F:26])([F:25])[C:10](=[O:24])[CH2:11][C:12]([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13])(=O)OCC)C.[OH-].[Na+]>CO.O>[F:26][CH:9]([F:25])[C:10](=[O:24])[CH2:11][C:12]([CH3:13])([C:15]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])[CH3:14]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 57809801[1,1-Difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester

Produkt 1

HCID 578099691,1,-Difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-oneAusbeute 95,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of [1,1-difluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentyl]phosphonic acid diethyl ester (1.0 g) in methanol (12.0 mL) was added a solution of sodium hydroxide (0.04 g) in water (1 mL). The mixture was stirred at room temperature for 30 minutes. The mixture was diluted with hexanes (50 mL) and water (50 mL) and the organic phase was separated, dried, filtered, and evaporated in vacuo to give 1,1,-difluoro-4-methyl-4-(2-methoxy-5-fluorophenyl)pentan-2-one (0.63 g) as an oil which was used without additional purification.

Aufarbeitung

  1. customthe organic phase was separated
  2. customdried
  3. filtrationfiltered
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0044ed8a235c45e4b1ac87f2acfb4a03
Quelldatensatz
uspto-grants-2009_08
Patentnummer
US07579469B2

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