Hydrogen Peroxide → Pyridine, 3-methoxy-, 1-oxide

Temperatur

70 °C

3-Methoxypyridine (20.08 g, 209 mmol) was dissolved in 100 mL of acetic acid. 30% H2O2 (28.3 mL, 275 mmol) was added and the reaction mixture was heated at 70° C. for six h. The cooled reaction mixture was concentrated and the residue dissolved in CH2Cl2 and stirred overnight with 20 g of solid potassium carbonate. The mixture was filtered and concentrated to give compound 762A (25.2 g, 100%) as a light yellow solid which was characterized by 1H NMR and carried on to the next step.

1. customThe cooled reaction mixture
2. concentrationwas concentrated
3. dissolutionthe residue dissolved in CH2Cl2
4. filtrationThe mixture was filtered
5. concentrationconcentrated

ORD-Eintrag

ord-8ae969bbd7bd43cc9783fa0bf4397708

Quelldatensatz

uspto-grants-2009_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07517904B2