Butylamine → N2-butyl-9H-purine-2,6-diamine

HRID 2111659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2111659
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

Komponenten

3

Edukt 2

HCID 8007ButylamineHCID 949042-Chloroadenine

Produkt 1

HCID 3487963N2-butyl-9H-purine-2,6-diamine

Versuchsvorschrift

2-Chloroadenine (6.0 g, 35.4 mmol) and butylamine (30 ml) were placed in an autoclave (200 ml), and the content of the autoclave was allowed to react at 130° C. for 150 hours. The reaction solution was concentrated under reduced pressure, and water was poured into the residue to precipitate a solid. The precipitated solid was sequentially washed with methylene chloride and methanol. Thus, 2.08 g of the title compound was obtained as a yellowish orange powdery solid (yield: 30%).

Aufarbeitung

  1. customto react at 130° C. for 150 hours
  2. concentrationThe reaction solution was concentrated under reduced pressure, and water
  3. additionwas poured into the residue
  4. customto precipitate a solid
  5. washThe precipitated solid was sequentially washed with methylene chloride and methanol

Quellen und Nachweise

ORD-Eintrag
ord-4662ebd422494a8b905ccb14310db0af
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07521454B2

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