Water → HCID 178487895, Verbindung

HRID 2112101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2112101
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][C:18](O)=[O:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].O>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][CH2:18][OH:19])[N:16]=2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]

Komponenten

4

Edukt 2

HCID 962WaterHCID 178487908HCID 178487908, Verbindung

Produkt 1

HCID 178487895HCID 178487895, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1.45 g (5.23 mmol) [2-(3-methoxy-4-nitro-phenyl)-1H-imidazol-4-yl]-acetic acid are dissolved in 36 ml THF and cooled to 0° C. and combined with 10 ml (18 mmol) borane-THF complex (1.8 mol/V). After 1 h the mixture is heated to 20° C. and stirred for 16 h. Water is added until the development of gas has ended. Then the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate. The organic phases are combined, dried and freed from the solvent in vacuo.

Aufarbeitung

  1. temperatureAfter 1 h the mixture is heated to 20° C.
  2. extractionThen the mixture is extracted twice with saturated aqueous sodium hydrogen carbonate solution and ethyl acetate
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-756862ec6c424e9dab147694a5d8f477
Quelldatensatz
uspto-grants-2009_04
Patentnummer
US07521457B2

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