7-Dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one → 7-Amino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one
Reaktionsgleichung
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22])C1C=CC=CC=1>CO.[Pd]>[NH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[C:16](=[O:18])[N:15]([CH2:19][CH2:20][F:21])[C:14]2([CH3:23])[CH3:22]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
75 mg (0.188 mmol) 7-dibenzylamino-2-(2-fluoro-ethyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one are dissolved in 50 ml of methanol and combined with 10 mg palladium on charcoal. The mixture is hydrogenated for 16 h at 5 bar H2 pressure and ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
Aufarbeitung
- filtrationThen the catalyst is filtered off
Quellen und Nachweise
- ORD-Eintrag
- ord-a2c4dccc7c114ef3a319530cc007410d
- Quelldatensatz
- uspto-grants-2009_04
- Patentnummer
- US07521457B2
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