1-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazole → 5-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

HRID 2114271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114271
[C:1]([O:5][C:6]([N:8]1[C:12]([N+:13]([O-])=O)=[CH:11][C:10]([C:16]([O:18][CH3:19])=[O:17])=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>[Pd]>[NH2:13][C:12]1[N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[N:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[CH:11]=1

Komponenten

4

Edukt 2

HCID 597735771-tert-Butoxycarbonyl-3-methoxycarbonyl-5-nitropyrazoleHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 597733355-Amino-1-tert-butoxycarbonyl-3-methoxycarbonylpyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

A mixture of 1.0 eq. of 19 and 0.1 wt/wt eq. of 10% Pd on carbon was hydrogenated at 10-60 psi of hydrogen for a time sufficient for reaction completion. The reaction mixture was filtered through Celite. The filtrate was concentrated by rotary evaporation. The crude material was dried under vacuum to give product 20.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationThe filtrate was concentrated by rotary evaporation
  3. dry with materialThe crude material was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6ce485c14eb14fb0a5b5ade4c8ec95d2
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07432379B2

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