Methyl iodide → 7-Fluoro-1-methylindoline-2,3-dione

HRID 2114863Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114863
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=[O:12].IC.[C:15](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:15])[C:8](=[O:11])[C:7]2=[O:12]

Komponenten

6

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 5864187-Fluoroisatin

Produkt 1

HCID 118459677-Fluoro-1-methylindoline-2,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

7-Fluoro-1H-indole-2,3-dione (5, prepared according to the method of Gassman as described in U.S. Pat. No. 4,188,325, 3.00 g, 0.182 mol), iodomethane (3.40 ml, 0.545 mol) and potassium carbonate (4.92 g, 0.0363 mol) in DMF (15 ml) are stirred at room temperature for 1 hour. The reaction mixture is diluted with cold water and the resulting precipitate filtered and dried to give the title compound as a solid. HPLC r.t. 4.01 min; MS for C9H6FNO2 m/z 180.0 (M+H)+.

Aufarbeitung

  1. filtrationthe resulting precipitate filtered
  2. customdried

Quellen und Nachweise

ORD-Eintrag
ord-89470784ae1f45628126e5c3981a3ab7
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435751B2

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