7-Fluoro-1-methylindoline-2,3-dione → 7-Fluoro-1-methylindolin-2-one

HRID 2114864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114864
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[C:7]2=O>O.NN>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[CH2:7]2

Komponenten

3

Edukt 1

HCID 118459677-Fluoro-1-methylindoline-2,3-dione

Produkt 1

HCID 119516747-Fluoro-1-methylindolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24654Hydrazine hydrate (1:1)Lösungsmittel

Versuchsvorschrift

7-Fluoro-1-methyl-1H-indole-2,3-dione (6, 2.48 g, 0.0138 mol) is heated with neat hydrazine hydrate (30 ml) at 130° C. for 30 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as a solid. HPLC r.t. 4.07 min; MS for C9H8FNO m/z 165.16 (M+H)+.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-fc5b0e397e1b4beabe3556877bc5b85f
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435751B2

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