7-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione → 7-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

HRID 2114885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2114885
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[C:7]2=O>O.NN>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2

Komponenten

3

Edukt 1

HCID 739475787-Fluoro-1-(2-fluoroethyl)indoline-2,3-dione

Produkt 1

HCID 739475797-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24654Hydrazine hydrate (1:1)Lösungsmittel

Versuchsvorschrift

7-Fluoro-1-(2-fluoro-ethyl)-1H-indole-2,3-dione (1.04 g, 4.92 mmol) is heated with neat hydrazine hydrate (10 ml) at 130° C. for 20 minutes. The mixture is cooled, diluted with ice water and extracted with ethyl acetate. The extract is washed with brine, dried (Na2SO4), and evaporated to give the title compound as a brown solid. HPLC r.t. 4.36 min; MS for C10H9F2NO m/z 198.1 (M+H)+.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5bfc516fcc2c46f9bdc26ad529cf186c
Quelldatensatz
uspto-grants-2008_10
Patentnummer
US07435751B2

Notizen zur Reaktion

Wird geladen…