7,8-Dihydro-6H-isoquinolin-5-one oxime → 5,6,7,8-Tetrahydroisoquinolin-5-amine
Reaktionsgleichung
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][C:6](=[N:11]O)[C:5]=2[CH:4]=[CH:3][N:2]=1>C(O)C.C(OCC)(=O)C.[Pd]>[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][N:2]=1Komponenten
5
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
To a solution of 7,8-dihydroisoquinolin-5-(6H)-one oxime [Synth. Commun., 26(12), 2305-2308, (1996)] (1 g, 6.2 mmol) in ethanol (20 ml) and ethyl acetate (1 ml) was added 10% palladium on carbon (250 mg). The resulting slurry was stirred under a hydrogen balloon at room temperature for 20 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound as a brown oil (953 mg, 100%). m/z (ES+) 149 (M+H+).
Aufarbeitung
- customThe catalyst was removed by filtration
- customthe solvent evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-fe3ee84a4e354d75a2ea03d47974f8a8
- Quelldatensatz
- uspto-grants-2008_10
- Patentnummer
- US07442701B2
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