Chloral Hydrate → N-[2-(3,4-dimethoxyphenyl)ethyl]formamide

HRID 2118503

Reaktionsgleichung

Reaktionsgleichung von HRID 2118503
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].ClC(Cl)(Cl)[CH:16](O)[OH:17].C(Cl)(Cl)Cl>O>[CH:16]([NH:13][CH2:12][CH2:11][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)=[O:17]

Komponenten

5

Edukt 3

HCID 2707Chloral HydrateHCID 6212ChloroformHCID 8421Homoveratrylamine

Produkt 1

HCID 84337N-[2-(3,4-dimethoxyphenyl)ethyl]formamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

First, 2-(3,4-dimethoxyphenyl)-ethylamine (181.2 g, 1 mol) and chloral hydrate (181 g, 1.1 mol) are mixed together and heated to 120° C., with stirring, for 20 minutes and any volatile components (chloroform and water) are eliminated in a water jet vacuum at an oil bath temperature of 140° C. An oil is left behind which is further processed without any purification.

Aufarbeitung

  1. customtemperature of 140° C
  2. waitAn oil is left behind which
  3. customis further processed without any purification

Quellen und Nachweise

ORD-Eintrag
ord-e687a79b375e40ad8ca7776ad80c5a88
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04678792

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