Hydrazine hydrate (1:1) → 1-Amino-8-(1-naphthyloxy)octane

HRID 2118659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2118659
[C:1]1([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20]2C(=O)C3=CC=CC=C3C2=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O.NN>C(O)C>[NH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][O:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 13520543N-8-(1-naphthyloxy)octylphthalimide

Produkt 1

HCID 135205411-Amino-8-(1-naphthyloxy)octane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 10.0 g N-[8-(1-naphthyloxy)octyl]phthalimide, prepared as above, and 200 ml of ethanol and 3.2 ml of hydrazine hydrate was refluxed for 18 hours. The solution was evaporated to about 100 ml, and diluted with 200 ml of water, then basified with aqueous potassium hydroxide and extracted with hexane. The extract was washed, dried and evaporated to give the title compound as an oil which was converted to the hydrochloride, mp 90.5°-92°.

Aufarbeitung

  1. temperaturewas refluxed for 18 hours
  2. customThe solution was evaporated to about 100 ml
  3. additiondiluted with 200 ml of water
  4. extractionextracted with hexane
  5. washThe extract was washed
  6. customdried
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8730f934c84d41ea84f6537e8950a6b8
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04680300

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