HCID 13633455, Verbindung → HCID 13633450, Verbindung

HRID 2118676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2118676
[C:1]1([C:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.[Pd]>[C:26]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][N:16]3[C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[NH:18][C:17]3=[O:25])[CH2:12][CH2:13]2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Komponenten

5

Edukt 2

HCID 13633455HCID 13633455, VerbindungHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 13633450HCID 13633450, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 4 g of 1-[2-[4-diphenylmethylene-1-piperidinyl]ethyl]-1,3-dihydro-2(2H)-benzimidazolone in 150 cm3 of methanol is hydrogenated with the aid of a Parr apparatus, at ambient temperature, at a hydrogen pressure of 50 psi, in the presence of 5% palladium on charcoal. When the absorption of hydrogen has ended, the catalyst is filtered off and the filtrate is evaporated down. The product obtained is recrystallized from ethyl acetate. M.p.=195°-196° C.

Aufarbeitung

  1. customWhen the absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. customthe filtrate is evaporated down
  4. customThe product obtained
  5. customis recrystallized from ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-bffebfb5aeac405ba97867809734a1b0
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04680296

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