Potassium Carbonate → 2-(2-Chloroethoxy)benzene-1-sulfonamide

HRID 2118928

Reaktionsgleichung

Reaktionsgleichung von HRID 2118928
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].C1(C)C=CC(C(S(O[CH2:30][CH2:31][Cl:32])(=O)=O)=O)=CC=1>C(C(C)=O)C>[Cl:32][CH2:31][CH2:30][O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamideHCID 539698672-Chloroethyl p-toloylsulfonate

Produkt 1

HCID 137294542-(2-Chloroethoxy)benzene-1-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 9.0 g of 2-hydroxyphenylsulfonamide, 7.9 g of potassium carbonate, 13.3 g of 2-chloroethyl p-toloylsulfonate and 80 ml of ethylmethylketone is refluxed for 40 hours. The reaction mixture is cooled to room temperature, filtrated and evaporated to dryness. From the oily residue crystallise after addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

Aufarbeitung

  1. temperatureis refluxed for 40 hours
  2. filtrationfiltrated
  3. customevaporated to dryness
  4. customFrom the oily residue crystallise
  5. additionafter addition of a small portion of methylene chloride 7.0 g of 2-(2-chloroethoxy)-phenylsulfonamide, m.p. 110° C.

Quellen und Nachweise

ORD-Eintrag
ord-086e0da574614fe2b03935b0070c2db1
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04681619

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