Ethanol → HCID 15839201, Verbindung

HRID 2119428Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2119428
[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3](N)=[O:4].[CH2:20]([OH:22])[CH3:21]>O>[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3]([O:22][CH2:20][CH3:21])=[O:4]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 15839202HCID 15839202, Verbindung

Produkt 1

HCID 15839201HCID 15839201, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2.15 g (8.4 mmol) of 2-hydroxy-3,3-diphenylbutyramide were dissolved in 15 ml of ethanol, 15 ml of conc. HCI were added and the mixture was refluxed for 40 hours. The solvent was stripped off under reduced pressure, and the residue was taken up in water. The aqueous phase was extracted three times with ethyl acetate, and the combined organic phases were washed twice with 10% strength sodium hydroxide solution. Drying with MgSO4 and stripping off the solvent under reduced pressure resulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate.

Aufarbeitung

  1. addition15 ml of conc. HCI were added
  2. temperaturethe mixture was refluxed for 40 hours
  3. extractionThe aqueous phase was extracted three times with ethyl acetate
  4. washthe combined organic phases were washed twice with 10% strength sodium hydroxide solution
  5. dry with materialDrying with MgSO4
  6. customresulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate

Quellen und Nachweise

ORD-Eintrag
ord-814c512e81664f438b7093d9be2d38d5
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06686369B1

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