Acetone → 3-Butyl-6-(isopropylamino)-phthalide

HRID 2120183

Reaktionsgleichung

Reaktionsgleichung von HRID 2120183
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[CH3:16][C:17]([CH3:19])=O>C(O)C.[Pd]>[CH2:12]([CH:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][CH:17]([CH3:19])[CH3:16])=[CH:3][CH:4]=2)[C:8](=[O:9])[O:7]1)[CH2:13][CH2:14][CH3:15]

Komponenten

5

Edukt 2

HCID 180AcetoneHCID 98777066-Amino-3-butyl-phthalide

Produkt 1

HCID 99648533-Butyl-6-(isopropylamino)-phthalide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4.1 g (20.0 mmol) of compound obtained in Example 4 in 4 ml of acetone and 96 ml of anhydrous ethanol there is added 10% Pd—C catalyst. The mixture is hydrogenated under a hydrogen pressure of 3-3.5 kg/cm2. After the absorption of hydrogen is complete, the catalyst is filtered off and the filtrate is concentrated in vacuo to dryness. The residue is crystallised from dilute ethanol to give the title compound.

Aufarbeitung

  1. customAfter the absorption of hydrogen
  2. filtrationthe catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo to dryness
  4. customThe residue is crystallised from dilute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8484c0784fa546faa001dddbf1c438e2
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06689808B2

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