Water → 2-(Benzenesulfonyl)acetamide

HRID 2120280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2120280
Br[CH2:2][C:3]([NH2:5])=[O:4].[C:6]1([S:12]([O:14][Na])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O>CN(C=O)C>[C:6]1([S:12]([CH2:2][C:3]([NH2:5])=[O:4])(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 696322-BromoacetamideHCID 178527445HCID 178527445, Verbindung

Produkt 1

HCID 18103052-(Benzenesulfonyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of α-bromoacetamide IV in anhydrous DMF, is added PhSO2Na at 0° C. The reaction mixture is stirred for 1 hour at room temperature and is then poured into water. The organic layer is washed with brine, dried over Na2SO4, and evaporated. The residue is purified by silica gel column chromatography to give α-phenylsulfonylacetamide III.

Aufarbeitung

  1. washThe organic layer is washed with brine
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customThe residue is purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-65266f6a96dc47279dedb4650eca1c6a
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06689890B2

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