Bromine → 3-Bromopiperidin-4-one hydrobromide

HRID 2121453Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2121453
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[CH2:10][CH2:9]1)=O)CCC.[Br:15]Br>C(Cl)(Cl)Cl>[BrH:15].[Br:15][CH:10]1[C:11](=[O:14])[CH2:12][CH2:13][NH:8][CH2:9]1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 22732029Butyl 4-oxopiperidine-1-carboxylate

Produkt 1

HCID 141969683-Bromopiperidin-4-one hydrobromideAusbeute 163,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

About 2.6 g of N-butoxycarbonyl-4-piperdone (FIG. 10b) was dissolved in about 70 ml of chloroform; to this solution was added about 2.08 g Br2 over a period of about 30 minutes. The reaction was continued for about 2 hours at room temperature during which a white precipitate of the compound of FIG. 10c was formed. The reaction mixture was filtered and washed with chloroform ether to yield about 2.76 g of the compound of FIG. 10c.

Aufarbeitung

  1. customa white precipitate of the compound of FIG. 10c was formed
  2. filtrationThe reaction mixture was filtered
  3. washwashed with chloroform ether

Quellen und Nachweise

ORD-Eintrag
ord-530324277cb844d0bac02d64ffa9875b
Quelldatensatz
uspto-grants-2004_02
Patentnummer
US06696455B1

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