m-Nitroacetophenone → 2-Chloro-1-(3-nitrophenyl)ethanone
Reaktionsgleichung
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)([Cl:16])(=O)=O>C(OC(C)C)(C)C>[Cl:16][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3′-Nitroacetophenone (2.00 g) was dissolved in diisopropyl ether (12.1 ml) and sulfuryl chloride (6.70 g) was added all at once thereto at 22° C. and refluxed for 6.5 hours. The reaction mixture was allowed to cool to room temperature while stirring, and the precipitated solids were filtered and washed with diisopropyl ether. Drying under reduced pressure yielded the desired 2-chloro-3′-nitroacetophenone (2.01 g; 83.1%).
Aufarbeitung
- temperaturerefluxed for 6.5 hours
- filtrationthe precipitated solids were filtered
- washwashed with diisopropyl ether
- customDrying under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-51086aa603e145a4ab2999cf686bed9a
- Quelldatensatz
- uspto-grants-2004_02
- Patentnummer
- US06696573B1
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