Hydrogen Bromide → 3-Fluoro-4-hydroxybenzoic acid

HRID 21352

Reaktionsgleichung

Reaktionsgleichung von HRID 21352
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11]C)[C:5]([OH:7])=[O:6].Br>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 27334013-Fluoro-4-methoxybenzoic acid

Produkt 1

HCID 1604563-Fluoro-4-hydroxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Next, the 3-fluoro-4-methoxybenzoic acid (IV) was digested with HBr (20 ml) and glacial acetic acid (40 ml) overnight. Most of the acetic acid was distilled off and the remaining mixture was diluted with water. The precipitated benzoic acid was extracted in ether; the ether layer was dried, filtered and rotary evaporated to produce 11.0 g of the 3-fluoro-4-hydroxybenzoic acid (V).

Aufarbeitung

  1. distillationMost of the acetic acid was distilled off
  2. additionthe remaining mixture was diluted with water
  3. extractionThe precipitated benzoic acid was extracted in ether
  4. dry with materialthe ether layer was dried
  5. filtrationfiltered
  6. customrotary evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8e57d185e0ee46b387690b2c6fd8b245
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05422037

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