3-Methylpyrido(3,4-b)pyrazin-2(1H)-one → HCID 53669727, Verbindung

HRID 21527Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 21527
[CH3:1][C:2]1[C:3](=[O:12])[NH:4][C:5]2[C:10]([N:11]=1)=[CH:9][N:8]=[CH:7][CH:6]=2.[H][H]>CO.[Pd].[Pd].[C]>[CH3:1][CH:2]1[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[N:8][CH:9]=2)[NH:4][C:3]1=[O:12]

Komponenten

6

Edukt 2

HCID 217791363-Methylpyrido(3,4-b)pyrazin-2(1H)-oneHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 53669727HCID 53669727, VerbindungAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Methyl-1,4,6-triazanaphthalen-2(1H)-one (J. W. Clark-Lewis, R. P. Singh J. Chem. Soc. 1962, 3162) (3.1 g, 0.02 mol) was hydrogenated in 300 ml of methanol with palladium catalysis (10% Pd/carbon) under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, the solvent was removed, and the residue was stirred with diethyl ether and filtered off with suction. 2.6 g (82%) of the desired product of melting point 230° C. (dec.) were obtained.

Aufarbeitung

  1. filtrationthe catalyst was filtered off with suction
  2. customthe solvent was removed
  3. filtrationfiltered off with suction

Quellen und Nachweise

ORD-Eintrag
ord-b566065b42fe4b3faa3ce20642721aa8
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424311

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