Lithium Hydroxide → HCID 15780556, Verbindung

HRID 21573Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 21573
[C:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:10][C:11](=[O:15])[O:12]2)=[CH:7][CH:6]=1)([O:3]C)=[O:2].[Li+].[OH-].C1COCC1>CO>[C:16]1([C:9]2[C:8]3[C:13](=[CH:14][C:5]([C:1]([OH:3])=[O:2])=[CH:6][CH:7]=3)[O:12][C:11](=[O:15])[CH:10]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 15780555HCID 15780555, Verbindung

Produkt 1

HCID 15780556HCID 15780556, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 7-carbomethoxy-4-phenylcoumarin (510 mg), 1N LiOH (10 mL), THF (7 mL) and MeOH (10 mL) was heated at reflux for 1 hr. The solution was concentrated then H2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added and stirring continued for 1 hr. After this time, the organic layer was separated and concentrated to yield the title compound which was used as such in the next step.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1 hr
  3. concentrationThe solution was concentrated
  4. additionH2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added
  5. customAfter this time, the organic layer was separated
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3ff8235e618c4a32a2e70fcb9996f07b
Quelldatensatz
uspto-grants-1995_06
Patentnummer
US05424320

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