Dimethylformamide → 5-Bromo-pyridine-2-carbonyl chloride

HRID 215961

Reaktionsgleichung

Reaktionsgleichung von HRID 215961
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.C(Cl)(=O)C([Cl:14])=O.CN(C)C=O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([Cl:14])=[O:10])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 6085445-Bromopyridine-2-carboxylic acid

Produkt 1

HCID 190907715-Bromo-pyridine-2-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a mixture of 5-bromopyridine-2-carboxylic acid (2.5 g, 12 mmol) in methylene chloride (10.0 mL) was added oxalyl chloride (1.6 mL, 18 mmol), followed by N,N-dimethylformamide (0.020 mL, 0.26 mmol). After stirred at RT for 2 h, the mixture was evaporated under reduced pressure. The residue was the acid chloride which was used directly in next step reaction.

Aufarbeitung

  1. customthe mixture was evaporated under reduced pressure
  2. customwas used directly in next step reaction

Quellen und Nachweise

ORD-Eintrag
ord-44363defda564c4996b698d619dbe1e3
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193207B2

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