Ethyl bromoacetate → Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

Reaktionsgleichung

[Br:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>>[BrH:1].[CH2:6]([O:5][C:3](=[O:4])[CH2:2][N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]1=[NH:8])[CH3:7]

Komponenten

Edukt 2

HCID 7748Ethyl bromoacetate

HCID 104392-Aminopyridine

Produkt 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

Versuchsvorschrift

To 39 mL (0.35 mol) of ethyl bromoacetate is added 9.4 g (0.1 mol) of 2-aminopyridine portionwise at 0° C. The resulting mixture is allowed to warm to room temperature and stirred at this temperature for 30 minutes. The precipitate is collected and washed with hexane to give the desired compound as light tan solid.

Aufarbeitung

customThe precipitate is collected
washwashed with hexane

Quellen und Nachweise

ORD-Eintrag: ord-139322c54df1428e9f9697ab542f9be2
Quelldatensatz: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08193214B2

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