Sodium borohydride → HCID 59176789, Verbindung

HRID 215967Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 215967
[BH4-].[Na+].[C:3]1([CH:13]=[C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][C:15]2=[O:23])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1>C(O)C.CO>[C:3]1([CH2:13][CH:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][C:15]2=[O:23])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=1

Komponenten

5

Edukt 2

HCID 4311764Sodium borohydrideHCID 686995473-[1-Naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one

Produkt 1

HCID 59176789HCID 59176789, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
-78 °C

Versuchsvorschrift

To a suspension of 137 mg (3.7 mmol) of sodium borohydride in 15 mL of ethanol is added a solution of 500 mg (1.8 mmol) of 3-[1-naphthalen-1-yl-methylidene]-imidazo[1,2-a]pyridin-2-one in 50 mL of methanol, dropwise at −78° C. After stirring for 10 min at −78° C., the reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C. The product is extracted with dichloromethane. The organic layer is dried over magnesium sulfate, filtered and concentrated in vacuo to give the desired compound.

Aufarbeitung

  1. customdropwise at −78° C
  2. customthe reaction mixture is quenched with saturated aqueous ammonium chloride solution at −78° C
  3. extractionThe product is extracted with dichloromethane
  4. dry with materialThe organic layer is dried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-22fb3b9ad2bc48f99a18ffab9dce5bc0
Quelldatensatz
uspto-grants-2012_06
Patentnummer
US08193214B2

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