Pyridine → Acetoacetic Acid

HRID 2163162

Reaktionsgleichung

Reaktionsgleichung von HRID 2163162
[OH:1][CH:2]1[CH2:6][CH:5]([OH:7])[CH:4]=C1.N1C=CC=CC=1.[C:14]([O:17]C(=O)C)(=[O:16])[CH3:15]>>[CH3:15][C:14]([O-:17])=[O:16].[CH3:4][C:5]([CH2:6][C:2]([OH:16])=[O:1])=[O:7]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 2786004-Cyclopentene-1,3-diol

Produkt 2

HCID 96Acetoacetic AcidHCID 175Acetate

Versuchsvorschrift

To a mixture of 1.50 grams (15 mmols) of 3,5-dihydroxycyclopent-1-ene and 1.0 milliliter (120 mmols) of pyridine was added 972 milligrams (9.5 mmols) of acetic anhydride, the addition being made over a period of 7.5 hours with stirring. The aftertreatment was then carried out as in Example 1 to obtain 0.62 gram of a crude product. When calculations were made from the results of the gas chromatographic analysis, the yields of monoacetate and diacetate were 22% and 5%, respectively.

Aufarbeitung

  1. additionthe addition
  2. customto obtain 0.62 gram of a crude product
  3. customresults of the gas chromatographic analysis

Quellen und Nachweise

ORD-Eintrag
ord-36c72a69827748b0a61877543ba4f1d1
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04132726

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