Benzocaine → Ethyl 4-(15-methylhexadecyl)aminobenzoate

HRID 2163778

Reaktionsgleichung

Reaktionsgleichung von HRID 2163778
[CH3:1][CH:2]([CH3:18])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br.[NH2:19][C:20]1[CH:30]=[CH:29][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:22][CH:21]=1.CN(C)P(N(C)C)(N(C)C)=O>O>[CH3:1][CH:2]([CH3:18])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:19][C:20]1[CH:21]=[CH:22][C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:29][CH:30]=1

Komponenten

5

Edukt 3

HCID 2337BenzocaineHCID 12679HexamethylphosphoramideHCID 2043738515-Methylhexadecyl bromide

Produkt 1

HCID 20437391Ethyl 4-(15-methylhexadecyl)aminobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 5 g. of 15-methylhexadecyl bromide and 5.2 g. of ethyl 4-aminobenzoate in 50 ml. hexamethylphosphoramide is heated for 17 hours at 120° C. The cooled solution is diluted with an equal volume of water and the resultant precipitate is filtered, washed with 100 ml. of 50% ethanol, dried, and crystallized from ethanol to yield a colorless crystalline solid.

Aufarbeitung

  1. additionA mixture of 5 g
  2. filtrationthe resultant precipitate is filtered
  3. washwashed with 100 ml
  4. dry with materialof 50% ethanol, dried
  5. customcrystallized from ethanol
  6. customto yield a colorless crystalline solid

Quellen und Nachweise

ORD-Eintrag
ord-557ff9b5bd514921ae43a2424a11f1a3
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04136256

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