Water → HCID 13060090, Verbindung

HRID 2164059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164059
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([C:10](OC)=[O:11])[N:7]=[C:4]2[S:5][CH:6]=1.O>C1C=CC=CC=1.C1COCC1>[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:4]2[S:5][CH:6]=1

Komponenten

5

Edukt 2

HCID 962WaterHCID 13060080Methyl 3-methylimidazo[2,1-b]thiazole-6-carboxylate

Produkt 1

HCID 13060090HCID 13060090, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 241BenzeneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

100 ml of a 70% solution of NaAlH2 (CH3OCH2CH2O)2 in benzene are dropped at 25° into a suspension of 25 g of 3-methyl-6-carbomethoxy-imidazo-(2,1-b)thiazole, prepared as described in Example 8, in 250 ml of dry THF. The suspension is stirred for 2 hours at room temperature and thereafter 25 ml of water are slowly added. The suspension is then filtered and the filtrate concentrated to yield 21 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole; m.p. 155°-156° (methyl-ethyl-ketone).

Aufarbeitung

  1. customprepared
  2. filtrationThe suspension is then filtered
  3. concentrationthe filtrate concentrated

Quellen und Nachweise

ORD-Eintrag
ord-a037dbcc2d9d4839a192e8475a7651dd
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04137320

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