Pyridine → HCID 23462411, Verbindung

HRID 2164063Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164063
[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][OH:11])[N:7]=[C:4]2[S:5][CH:6]=1.[C:12]([Cl:17])(=[O:16])[CH2:13][CH2:14][CH3:15].N1C=CC=CC=1>C(Cl)(Cl)Cl>[ClH:17].[CH3:1][C:2]1[N:3]2[CH:9]=[C:8]([CH2:10][O:11][C:12](=[O:16])[CH2:13][CH2:14][CH3:15])[N:7]=[C:4]2[S:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 13060090HCID 13060090, Verbindung

Produkt 1

HCID 23462411HCID 23462411, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

A solution of 5 g of 3-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole in 100 ml of dry chloroform is dropped at 35° into a solution of 15 ml of butyroyl chloride and 12 ml of pyridine in 75 ml of dry chloroform. The suspension obtained is stirred for 1 hour at room temperature and then filtered. The filtrate is concentrated by evaporation. The residue obtained is dissolved in abs.ethanol and a stream of dry hydrochloric acid is bubbled into the solution to yield 4.5 g of 3-methyl-6-butyroxymethyl-imidazo-(2,1-b)thiazole hydrochloride; m.p. 126°-128°.

Aufarbeitung

  1. customThe suspension obtained
  2. filtrationfiltered
  3. concentrationThe filtrate is concentrated by evaporation
  4. customThe residue obtained
  5. dissolutionis dissolved in abs
  6. customethanol and a stream of dry hydrochloric acid is bubbled into the solution

Quellen und Nachweise

ORD-Eintrag
ord-bf2b895b5a224b44a606c6fed5d281c3
Quelldatensatz
uspto-grants-1979_01
Patentnummer
US04137320

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