Hydrochloric Acid → 7-(2-Fluorobenzoyl)-indolin-2-one

HRID 2164299Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164299
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]2SC)=[O:5].[Sn].Cl>C(O)C>[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11]2)=[O:5]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 133942837-(2-Fluorobenzoyl)-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 133942867-(2-Fluorobenzoyl)-indolin-2-oneAusbeute 60,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 60 g (0.2 mole) of 7-(2-fluorobenzoyl)-3-methylthioindolin-2-one and 60 g (0.5 mole) of tin powder in one liter of 95% ethanol was heated to reflux and 150 ml of concentrated hydrochloric acid was added. Heating was continued for 18 hrs, then the mixture was cooled and the precipitate was collected by decanting the slurry from the remaining tin and filtering the slurry. The filter cake was recrystallized twice from absolute ethanol to give 31 g (60%) white needles, m.p. 209°-210° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureHeating
  4. temperaturethe mixture was cooled
  5. customthe precipitate was collected
  6. customby decanting the slurry from the remaining tin
  7. filtrationfiltering the slurry
  8. customThe filter cake was recrystallized twice from absolute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-9c96ec57725541ba8227d135cad2204b
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04503073

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