Methanol → 4-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxobutyric acid

HRID 2164395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2164395
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][C:6]([C:8]1[S:9][C:10]([CH2:13][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[CH:11][CH:12]=1)=[O:7].[OH-].[Na+].CO>O>[NH:18]1[CH:17]=[CH:16][N:15]=[C:14]1[CH2:13][C:10]1[S:9][C:8]([C:6](=[O:7])[CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:12][CH:11]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 704876864-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxo-butyric acid methyl ester

Produkt 1

HCID 704292984-[5-(1-Imidazolylmethyl)-thien-2-yl]-4-oxobutyric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 4.17 g of 4-[5-(1-imidazolylmethyl)-thien-2-yl]-4-oxo-butyric acid methyl ester, 0.8 g of sodium hydroxide and 20 ml of methanol is stirred at room temperature for 8 hours. The solvent is then stripped off and the residue is taken up in water. The solution is extracted several times with chloroform, and the chloroform phase is discarded. The aqueous solution is brought to about pH 7 with dilute hydrochloric acid and is concentrated to dryness. The residue is purified by column chromatography (silica gel/CHCl3 /methanol).

Aufarbeitung

  1. extractionThe solution is extracted several times with chloroform
  2. concentrationis concentrated to dryness
  3. customThe residue is purified by column chromatography (silica gel/CHCl3 /methanol)

Quellen und Nachweise

ORD-Eintrag
ord-ec16d96664ce4c5a8672c2a1e115f8be
Quelldatensatz
uspto-grants-1985_03
Patentnummer
US04504479

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